2026年

Li J, Hamamura K, Yoshida Y, Kawano S, Uchinomiya S, Xie J, Scuteri D, Ruan Y, Tanihara T, Fukuoka K, Zaitsu O, Tsurusaki F, Tsukamoto R, Nishi T, Fukuda T, Hamasaki T, Oyama K, Bagetta G, Ojida A, Shimizu K, Zhang C, Ohdo S, Naoya Matsunaga. Hericenone C Exhibits Anti-Nociceptive Effects through RORα-Mediated Suppression of TLR4 Transcription. Front Pharmacol. (https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1703176/abstract) 2026.

Tsuruta A, Fujimoto M, Hiraoka Y, Taniguchi A, Shiiba Y, Inoki T, Yamauchi T, Yoshida Y, Matsunaga N, Ohdo S, Koyanagi S. C-X-C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment. Int J Cancer. 2026 Mar 15;158(6):1740-1754.

Aramaki S, Tanihara T, Yoshida Y, Matsunaga N, Ohdo S, Mayanagi K. High-Resolution single particle analysis using a scintillator camera XF416 on CRYOARM300II at 300 kV. J Struct Biol. 2026 Jan 3;218(1):108286.

2025年

Yasukochi S, Yamakawa W, Taniguchi M, Itoyama S, Tsuruta A, Kusunose N, Yamauchi T, Nakamura R, Matsunaga N, Ohdo S, Koyanagi S. The Circadian Clock Component REV-ERB Is an Analgesic Target for Cancer-Induced Tactile Pain Hypersensitivity. J Neurosci. 2025 May 28;45(22):e1969242025.

Tanihara T, Yoshida Y, Ogino T, Tsurusaki F, Hamasaki K, Otsuki K, Fukuoka K, Oyama K, Tsuruta A, Hamamura K, Mayanagi K, Koyanagi S, Murakami Y, Ono M, Kuwano M, Ohdo S, Matsunaga N. Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer. J Biol Chem. (https://doi.org/10.1016/j.jbc.2025.110414), 2025.

Ji R, Ishikawa K, Tan W, Mori K, Tsukamoto R, Matsunaga N, Kiyohara K, Fukuda Y, Wada I, Isobe T, Tanihara T, Yoshida Y, Mayanagi K, Oyama K, Otsuki K, Hamamura K, Kikuchi H, Nakao S, Yoshida S, Kannan R, Ohdo S, Sonoda K. Liposome encapsulation enhances ripasudil therapeutic efficacy against proliferative vitreoretinal diseases: implications in advanced ocular treatment. Invest Ophthalmol Vis Sci. 66, 56, 2025.

Inoki T, Tsuruta A, Masakado Y, Kai Y, Yoshida Y, Matsunaga N, Ohdo S, Koyanagi S. N-acetyltransferase 10 promotes glioblastoma malignancy via mRNA stabilization of jumonji and AT-rich interaction domain containing 2. J Biol Chem. 301, 108544, 2025.

Matsuda M, Nishi T, Yoshida Y, Matsuda-Hayama C, Kumamoto T, Hamamura K, Kohro-Ikeda E, Yasuo S, Koyanagi S, Matsunaga N, Ohdo S. Dopamine receptor D3 affects the expression of Period1 in mouse cells via DRD3–ERK–CREB signaling. Biochem Biophys Res Commun. 752, 151470, 2025.

Yoshida Y, Tanihara T, Hamasaki K, Tsurusaki F, Fukuda T, Adachi S, Otsuki K, Nishikawa N, Fukuoka K, Tsukamoto R, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Ohdo S, Matsunaga N. Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense. Theranostics. 15, 340-361, 2025.

2024年

Yoshida Y, Tanihara T, Hamasaki K, Tsurusaki F, Fukuda T, Adachi S, Otsuki K, Nishikawa N, Fukuoka K, Tsukamoto R, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Ohdo S,
Matsunaga N.Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense.
Theranostics 2025; 15(2):340-361. doi:10.7150/thno.100748

Yamauchi T, Okano Y, Terada D, Yasukochi S, Tsuruta A, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S,
Ohdo S.Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT.
Cancer Metab. 2024 Aug 7;12(1):23. doi: 10.1186/s40170-024-00352-4.

Okano Y, Yamauchi T, Fukuzaki R, Tsuruta A, Yoshida Y, Tsurudome Y, Ushijima K, Matsunaga N, Koyanagi S,
Ohdo S.Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins.
J Biol Chem. 2024 Oct 15;300(11):107890. doi: 10.1016/j.jbc.2024.107890.

Kato Y, Ariyoshi K, Nohara Y, Matsunaga N, Shimauchi T, Shindo N, Nishimura A, Mi X, Kim SG, Ide T, Kawanishi E, Ojida A, Nakashima N, Mori Y, Nishida M. Inhibition of dynamin-related protein 1-filamin interaction improves systemic glucose metabolism.
Br J Pharmacol. 2024 Jul 10. doi: 10.1111/bph.16487. Online ahead of print.

Yoshida Y, Fukuoka K, Sakugawa M, Kurogi M, Hamamura K, Hamasaki K, Tsurusaki F, Sotono K, Nishi T,Fukuda T, Kumamoto T, Oyama K, Ogino T, Tsuruta A, Mayanagi K, Yamashita T, Fuchino H, Kawahara N, Yoshimatsu K, Kawakami H, Koyanagi S, Matsunaga N, Ohdo S. Inhibition of G protein-coupled receptor8
using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment.
Transl Res. 2024 Jul;269:31-46. doi: 10.1016/j.trsl.2024.02.004. Epub 2024 Feb 23. PMID:38401836

Yoshida Y, Fukuda T, Fukuoka K, Nagayama T, Tanihara T, Nishikawa N, Otsuki K, HamamuraK, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S.Time-Dependent Differences in Vancomycin Sensitivity of Macrophages Underlie Vancomycin-Induced Acute Kidney Injury.
J Pharmacol Exp Ther. 2024 Jan 2;388(1):218-227. doi: 10.1124/jpet.123.001864. PMID: 38050132

Tsurudome Y, Yoshida Y, Hamamura K, Ogino T, Yasukochi S, Yasuo S, Iwamoto A, Yoshihara T, InazumiT, Tsuchiya S, Takeo T, Nakagata N, Higuchi S, Sugimoto Y, Tsuruta A, Koyanagi S, Matsunaga N, Ohdo S.Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior.
Int J Mol Sci. 2024 Feb 2;25(3):1841. doi: 10.3390/ijms25031841. PMID: 38339119 Free PMCarticle.

Yoshida Y, Fukuda T, Tanihara T, Nishikawa N, Iwasa S, Adachi S, Zaitsu O, Tsukamoto R, Shimoshikiryo H, Fukuoka K, Tsurusaki F, Hamamura K, Oyama K, Tsuruta A, Koyanagi S, Matsunaga N,Ohdo S. Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer.
Biochem Biophys Res Commun. 2024 May 14;708:149813. doi: 10.1016/j.bbrc.2024.149813. Epub 2024 Mar20.PMID: 38522403

Yamakawa W, Yasukochi S, Tsurudome Y, Kusunose N, Yamaguchi Y, Tsuruta A, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S. Suppression of neuropathic pain in the circadian clock-deficient Per2m/m mice involves up-regulation of endocannabinoid system.
PNAS Nexus. 2024 Jan 17;3(1):pgad482. doi: 10.1093/pnasnexus/pgad482. eCollection 2024 Jan. PMID: 38239754 Free PMC article.

Li J, Hamamura K, Yoshida Y, Kawano S, Uchinomiya S, Xie J, Scuteri D, Fukuoka K, Zaitsu O,Tsurusaki F, Tsukamoto R, Nishi T, Fukuda T, Oyama K, Bagetta G, Ojida A, Shimizu K, Ohdo S,Matsunaga N. Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65.
Biochem Biophys Res Commun. 2024 Aug 6;720:150077. doi: 10.1016/j.bbrc.2024.150077. Epub 2024 May14. PMID: 38759303 Free article.

Hamamura K, Yoshida Y, Oyama K, Li J, Kawano S, Inoue K, Toyooka K, Yamadera M, Matsunaga N, Matsumura T, Aritake K. Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy.
Int J Mol Sci. 2024 Feb 3;25(3):1846. doi: 10.3390/ijms25031846.

2023年

Yoshida Y, Fukuda T, Fukuoka K, Nagayama T, Tanihara T, Nishikawa N, Otsuki K, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S.
Time-dependent differences in vancomycin sensitivity of macrophages underlie vancomycin-induced acute kidney injury.
J Pharmacol Exp Ther. 2023 Nov 28:JPET-AR-2023-001864-T. doi: 10.1124/jpet.123.001864. Online ahead of print.

Fukuoka K, Yoshida Y, Sotono K, Nishikawa N, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S.
Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease.
Biochem Biophys Res Commun. 2023 Oct 1;675:92-98. doi: 10.1016/j.bbrc.2023.07.015. Epub 2023 Jul 10.

Yamane D, Tetsukawa R, Zenmyo N, Tabata K, Yoshida Y, Matsunaga N, Shindo N, Ojida A.
Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines.
J Med Chem. 2023 Jul 13;66(13):9130-9146. doi: 10.1021/acs.jmedchem.3c00737. Epub 2023 Jul 2.

Tsuruta A, Kanetani D, Shiiba Y, Inoki T, Yoshida Y, Matsunaga N, Koyanagi S, Ohdo S.
Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins.
Biochem Pharmacol. 2023 Sep;215:115708. doi: 10.1016/j.bcp.2023.115708. Epub 2023 Jul 26.

Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, Ushijima K, Yamashita T, Shindo N, Ojida A, Matsunaga N, Koyanagi S, Ohdo S.
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice.
Mol Pharmacol. 2023 Aug;104(2):73-79. doi: 10.1124/molpharm.123.000690. Epub 2023 Jun 14.

Uchinomiya S, Nagaura T, Weber M, Matsuo Y, Zenmyo N, Yoshida Y, Tsuruta A, Koyanagi S, Ohdo S, Matsunaga N,
Ojida A.
Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes.
J Am Chem Soc. 2023 Apr 12;145(14):8248-8260. doi: 10.1021/jacs.3c02043. Epub 2023 Apr 3.

Jaballah N, Tsurudome Y, Murakami C, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S.
The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells.
J Biochem. 2023 May 9:mvad035. doi: 10.1093/jb/mvad035. Online ahead of print.

2022年

Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacology of immune-related diseases.
Allergol Int. 2022 Oct;71(4):437-447. doi: 10.1016/j.alit.2022.06.006. Epub 2022 Jul 15.

Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T,
Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A.
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory
Syndrome Coronavirus 2 3CL Protease.J Med Chem. 2022 Oct 27;65(20):13852-13865.
doi:10.1021/acs.jmedchem.2c01081. Epub 2022 Oct 13.

Fujita Y, Murai M, Muraki S, Suetsugu K, Tsuchiya Y, Hirota T, Matsunaga N, Ieiri I.
Population Pharmacokinetic Analysis of Drug-drug Interactions between Perampanel and Carbamazepine
Using Enzyme Induction Model in Epileptic Patients.Ther Drug Monit. 2022 Oct 24. doi:
10.1097/FTD.0000000000001055. Online ahead of print.

Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4
via regulation of circRNA in human renal cells.J Biol Chem. 2022 Aug;298(8):102184. doi:
10.1016/j.jbc.2022.102184. Epub 2022 Jun 23.

Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S
Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice.
Mol Cancer Res. [Epub ahead of print], 2022 Feb 21

2021年

Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H, Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S.
Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis.Nat Commun. [Epub ahead of print], 2021 May 13

Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S.
Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells.
Elife. [Epub ahead of print], 2021 Apr 23

Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene.
J Biol Chem. [Epub ahead of print], 2021 Mar 26

Yasukochi S, Kusunose K, Matsunaga N, Koyanagi S, Ohdo S.
Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord.
Biochemical Pharmacology. [Epub ahead of print], 2021 Jan 8

2020年

Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi S, Ohdo S, Shindo N, Ojida A.
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins.
J Am Chem Soc. [Epub ahead of print], 2020 Oct 13

Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga N, Koyanagi S, Ohdo S.
Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity.Sci Rep. [Epub ahead of print], 2020 Aug 10

Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono M, Ojida A.Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.ACS Med Chem Lett. [Epub ahead of print], 2020 Jun 11

Kusunose N, Tsuruta A, Kengo Hamamura, Tsurudome Y, Yoshida Y, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.
Genes Cells. [Epub ahead of print], 2020 Feb 12

Uchinomiya S, Matsunaga N, Kamoda K, Kawagoe R, Tsuruta A, Ohdo S, Ojida A.
Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells.
Chem Commun (Camb). [Epub ahead of print], 2020 Feb 5

2019年

Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice.
Biol Pharm Bull. [Epub ahead of print], 2019 Nov 1

Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.
Biochem Biophys Res Commun. [Epub ahead of print], 2019 Sep 17

Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M.
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex.
Br J Pharmacol. [Epub ahead of print], 2019 Jun 26

Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacological strategies focused on chrono-drug discovery.
Pharmacol Ther. [Epub ahead of print], 2019 Jun 4

Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S.
Microcurrent stimulation activates the circadian machinery in mice.
Biochem Biophys Res Commun. [Epub ahead of print], 2019 Feb 26

Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Nat Chem Biol. [Epub ahead of print], 2019 Jan 14

2018年

Katamune C, Koyanagi S, Hashikawa K, Kusunose N, Akamine T, Matsunaga N, Ohdo S.
Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
J Biol Chem. [Epub ahead of print], 2018 Nov 14

Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T.
Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells.
Jpn J Ophthalmol. [Epub ahead of print], 2018 Sep 24

Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S.
Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
Biochem Biophys Res Commun. [Epub ahead of print], 2018 Jun 30

Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.
Sci Rep. [Epub ahead of print], 2018 Jun 13

Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model.
Biochem Biophys Res Commun. [Epub ahead of print], 2018 May 9

Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.
Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase.
Cancer Res. [Epub ahead of print], 2018

Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
J Pharmacol Sci. 2018 Mar12

Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S.
Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice.
Biochem Biophys Res Commun. 2018 Feb 19

2017年

Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S.
Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.
J Biol Chem. [Epub ahead of print], 2017

Okazaki F, Matunaga N, Hamamura K, Suzuki K, Nakao T, Okazaki H, Kutsukake M, Fukumori S, Tsuji Y, To H.
Administering xCT inhibitors based on circadian clock improves antitumor effects.
Cancer Res. [Epub ahead of print], 2017

Hashikawa K, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis.
Sci Rep. 7(1):9995, 2017

Dilixiati A, Koyanagi S, Kusunose N, Matunaga N, Ohdo S.
Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.
J Pharmacol Sci. 134(4):211-217, 2017

Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Matsunaga N, Koyanagi S, Ohdo S.
Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells.
Eur J Pharmacol. 800:48-56, 2017

2016年

Tomohiro Shibata, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Yuichi Murakami, Ryuji Takahashi, Uhi Toh, Ken-ichi Ito, Shigehiro Ohdo, Maki Tanaka, Masayoshi Kage, Michihiko Kuwano and Mayumi Ono
Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression
Cancer Res. 77(2):545-556, 2016.

Mahitab Elsayed, Daisuke Kobayashi, Toshio Kubota, Naoya Matsunaga, Ryusei Murata, Yuko Yoshizawa, Natsuki Watanabe, Tohru Matsuura, Yuya Tsurudome, Takashi Ogino, Shigehiro Ohdo, Takao Shimazoe
Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study
Biol Pharm Bull. 39(8):1238-46, 2016.

Yuki Nakamura, Nobuhiro Nakano, Kayoko Ishimaru, Noriko Ando, Ryohei Katoh, Katsue Suzuki-Inoue, Satoru Koyanagki, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock
J Allergy Clin Immunol. 137(4):1226-1235, 2016.

Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, ohdo S.
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.
Nat Commun. 7:13102, 2016.

Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S.
Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.
EBioMedicine. pii: S2352-3964(16)30463-7, 2016. [Epub ahead of print]

Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.
Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.
J Biol Chem. 291:10541-10550, 2016.

Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Hara Y, Tsuruta A, Tsurudome Y, Ogino T, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S.
Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression.
J Biol Chem. 291:7017-7028, 2016.

Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
Alterations of hepatic metabolism in chronic kidney disease via D-box binding protein aggravate the renal dysfunction.
J Biol Chem. 291:4913-4927, 2016.

2015年

Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo S, Kubota T.
Mitomycin C modulates the circadian oscillation of clock gene Period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.
Biochem Biophys Res Commun. S0006-291: 30603-3, 2015.

Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguchi M, Matsunaga N, Ohdo S.
Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice.
J Pharmacol Exp Ther. 354: 65-72, 2015.

Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S.
Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys.
Mol Pharmacol. 87: 314-322, 2015.

Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.
Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.
Mol Pharmacol. 88: 29-37, 2015.

2014年

Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.
J Biol Chem. 289: 25296-25305, 2014.

Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.
Renal circadian clock regulates the dosing-time dependency of Cisplatin-induced nephrotoxicity in mice.
Mol Pharmacol. 85: 715-722, 2014.

Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.
24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks.
J Invest Dermatol. [Epub ahead of print], 2014.

Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S.
Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.
Cancer Res. 74: 543-551, 2014.

2013年

Matsunaga N, Okazaki F, Koyanagi S, Ohdo S.
Chrono-drug delivery system based on the circadian rhythm of transferrin receptor.
Nihon Rinsho. 71: 2200-2205, 2013.

Tomishima Y, Ishitsuka Y, Matsunaga N, Nagatome M, Furusho H, Irikura M, Ohdo S, Irie T.
Ozagrel hydrochloride, a selective thromboxane A?Esynthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
BMC Gastroenterol. 13: 21-30, 2013.

Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.
Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells.
Cancer Res. 73: 2639-2649, 2013.

Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.
Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum.
Mol Pharmacol. 83: 959-967, 2013

Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease.
Neuromolecular Med. 15: 238-251, 2013

2012年

Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto N, Teramoto N, Fujita K, Ohdo S, Iguchi H.
IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain.
Int J Mol Sci. 14: 515-526, 2012.

Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S.
Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.
Mol Pharmacol. 82: 264-270, 2012.

Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S.
Intestinal expression of mouse Abcg2/Bcrp gene is under the control of circadian clock-activating transcription factor-4 pathway.
J Biol Chem. 287: 17224-17231, 2012.

Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshimura Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S.
Time-dependent Interaction Between DEC2 and C/EBPα Underlies the Circadian Expression of CYP2D6 in Serum-shocked HepG2 Cells.
Mol Pharmacol. 81: 739-747, 2012.

Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.
Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.
Cancer Res. 72: 395-401, 2012.

2011年

Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner.
Toxicology.204-8, 2011.

Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, OhdoS.
cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene.
J Biol Chem.286: 32416-23, 2011.

Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.
Molecular basis of chronopharmaceutics.
J Pharm Sci.100: 3560-76, 2011.

Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacology.
Nihon Yakurigaku Zasshi.137: 115-9, 2011. Review.

Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.
Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes.
Toxicology.280: 144-51, 2011.

2010年

Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S.
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
Mol. Pain. 6: 83, 2010.

Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S.
Proxisome proliferator-activated receptor-alpha mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice.
Chronobiol. Int. 27: 1735-1753, 2010.

Fujioka T, Matsunaga N, Okazaki H, Koyanagi　S, Ohdo S.
Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic　cell death of mouse rectum carcinoma.
J. Pharmacol. Sci. 113: 353-361, 2010.

Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacological strategies: Intra- and inter-individual variability　of molecular clock.
Adv. Drug Deliv. Rev. 62: 885-897, 2010.

Okazaki F, Matsunaga, N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo, S.
Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice.
Cancer Res. 70: 6238-6246, 2010.

Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S.
Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner.
Mol. Pharmacol. 78: 135-141, 2010.

Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K,Koyanagi S, Ohdo, S.
Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice.
J. Pharmacol. Exp. Ther. 333: 782-787, 2010.

2009年

Kim J, Matsunaga N, Koyanagi S, Ohdo S.
Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.
Biochem Pharmacol.78(8),1075-1082,2009.

2008年

Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S.
Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice.
Gastroenterology 135: 1636-1644, 2008.

Matsunaga N, Ikeda M, Takiguchi T, Koyanagi S, and Ohdo S.
The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in the mouse liver.
Hepatology 48: 240-251, 2008.

Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S.
Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function.
Life Sci. 83: 574-580, 2008.

Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H, Soeda S, Ohdo S.
Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.
J. Pharmacol. Sci. 107: 401-407, 2008.

Terazono H, Hamdan A, Matsunaga N, Hayasaka N, Kaji H, Egawa T, Makino K, Shigeyoshi Y, Koyanagi S, Ohdo S.
Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances.
Biochem. Pharmacol. 75: 1616-1622, 2008.

2007年

Takiguchi T, Tomita M, Matsunaga N, Nakagawa H, Koyanagi S, Ohdo S.
Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells.
Pharmacogenet. Genomics 17:1047-1056, 2007.

2006年

Koyanagi S, Suyama H, Kuramoto Y, Matsunaga N, Takane H, Soeda S, Shimeno H, Higuchi S, Ohdo S.
Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver.
Endocrinology 147: 5037-5040, 2006.

Yamauchi A, Ichimiya T, Inoue K, Taguchi Y, Matsunaga N, Koyanagi S, Fukagawa T, Aramaki H, Higuchi S, Ohdo S.
Cell cycle dependent pharmacology of methotrexate in HL-60
J. Pharmacol. Sci. 99: 335-341, 2006.

-2005年

Yamauchi A, Ichimiya T, Inoue K, Taguchi Y, Matsunaga N, Koyanagi S, Fukagawa T, Aramaki H, Higuchi S, Ohdo S.
Cell cycle dependent pharmacology of methotrexate in HL-60.
J. Pharmacol. Sci. 99, 335-341, 2005.

Viyoch J, Matsunaga N, Yoshida M, To H, Higuchi S, Ohdo S.
Effect of haloperidol on mPer1 gene expression in mouse SCN.
J. Biol. Chem. 280 (8) 6309-6315, 2005.

Matsunaga N, Nakamura N, Yoneda N, Qin T, Terazono H, To H, Higuchi S, Ohdo S.　　　　　　　　　　　　　　　　　　　Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice.　　　　　　　　　　　 J. Pharmacol. Exp. Ther. 311(2)594-600,2004.

To H, Shin M, Tabuchi M, Sakaguchi H, Takeuchi A, Matsunaga N, Higuchi S, Ohdo S. Influence of dosing schedule on toxicity and antitumor effects of a combination of adriamycin and docetaxel in mice. Clin.Cancer. Res.10(2):762-9, 2004.