2023年
Yoshida Y, Fukuda T, Fukuoka K, Nagayama T, Tanihara T, Nishikawa N, Otsuki K, Terada Y, Hamamura K,
Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S.
Time-dependent differences in vancomycin sensitivity of macrophages underlie vancomycin-induced acute
kidney injury.
J Pharmacol Exp Ther. 2023 Nov 28:JPET-AR-2023-001864-T. doi: 10.1124/jpet.123.001864. Online ahead of
print.
Fukuoka K, Yoshida Y, Sotono K, Nishikawa N, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S,
Matsunaga N, Ohdo S.
Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease.
Biochem Biophys Res Commun. 2023 Oct 1;675:92-98. doi: 10.1016/j.bbrc.2023.07.015. Epub 2023 Jul
10.
Yamane D, Tetsukawa R, Zenmyo N, Tabata K, Yoshida Y, Matsunaga N, Shindo N, Ojida A.
Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting
of Cysteines.
J Med Chem. 2023 Jul 13;66(13):9130-9146. doi: 10.1021/acs.jmedchem.3c00737. Epub 2023 Jul 2.
Tsuruta A, Kanetani D, Shiiba Y, Inoki T, Yoshida Y, Matsunaga N, Koyanagi S, Ohdo S.
Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular
localization of organelle proteins.
Biochem Pharmacol. 2023 Sep;215:115708. doi: 10.1016/j.bcp.2023.115708. Epub 2023 Jul 26.
Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, Ushijima K, Yamashita T,
Shindo N, Ojida A, Matsunaga N, Koyanagi S, Ohdo S.
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in
NCTC 2472 Fibrosarcoma-Inoculated Mice.
Mol Pharmacol. 2023 Aug;104(2):73-79. doi: 10.1124/molpharm.123.000690. Epub 2023 Jun 14.
Uchinomiya S, Nagaura T, Weber M, Matsuo Y, Zenmyo N, Yoshida Y, Tsuruta A, Koyanagi S, Ohdo S,
Matsunaga N,
Ojida A.
Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone
Methide-Releasing Probes.
J Am Chem Soc. 2023 Apr 12;145(14):8248-8260. doi: 10.1021/jacs.3c02043. Epub 2023 Apr 3.
Jaballah N, Tsurudome Y, Murakami C, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S.
The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse
intestinal epithelial cells.
J Biochem. 2023 May 9:mvad035. doi: 10.1093/jb/mvad035. Online ahead of print.
2022年
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacology of immune-related diseases.
Allergol Int. 2022 Oct;71(4):437-447. doi: 10.1016/j.alit.2022.06.006. Epub 2022 Jul 15.
Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda
T,
Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E,
Ojida A.
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory
Syndrome Coronavirus 2 3CL Protease.J Med Chem. 2022 Oct 27;65(20):13852-13865.
doi:10.1021/acs.jmedchem.2c01081. Epub 2022 Oct 13.
Fujita Y, Murai M, Muraki S, Suetsugu K, Tsuchiya Y, Hirota T, Matsunaga N, Ieiri I.
Population Pharmacokinetic Analysis of Drug-drug Interactions between Perampanel and Carbamazepine
Using Enzyme Induction Model in Epileptic Patients.Ther Drug Monit. 2022 Oct 24. doi:
10.1097/FTD.0000000000001055. Online ahead of print.
Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein
MRP4
via regulation of circRNA in human renal cells.J Biol Chem. 2022 Aug;298(8):102184. doi:
10.1016/j.jbc.2022.102184. Epub 2022 Jun 23.
Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo
S
Diurnal expression of PD-1 on tumor-associated macrophages underlies the
dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1
in B16/BL6 melanoma-bearing mice.
Mol Cancer Res. [Epub ahead of print], 2022 Feb 21
2021年
Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H,
Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S.
Alteration of circadian machinery in monocytes underlies chronic kidney
disease-associated cardiac inflammation and fibrosis.Nat Commun. [Epub
ahead of print], 2021 May 13
Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada
Y, Tsuruta A, Koyanagi S, Ohdo S.
Post-transcriptional repression of circadian component CLOCK regulates
cancer-stemness in murine breast cancer cells.
Elife. [Epub ahead of print], 2021 Apr 23
Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein
in human renal cells by regulating alternative splicing of the ABCB1 gene.
J Biol Chem. [Epub ahead of print], 2021 Mar 26
Yasukochi S, Kusunose K, Matsunaga N, Koyanagi S, Ohdo S.
Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through
inhibition of SGK-1 in the spinal cord.
Biochemical Pharmacology. [Epub ahead of print], 2021 Jan 8
2020年
Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi
S, Ohdo S, Shindo N, Ojida A.
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile
for Selective Targeting of Proteins.
J Am Chem Soc. [Epub ahead of print], 2020 Oct 13
Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga
N, Koyanagi S, Ohdo S.
Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time
dependent changes in the oxaliplatin-induced myelotoxicity.Sci Rep. [Epub
ahead of print], 2020 Aug 10
Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori
R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono
M, Ojida A.Selective Covalent Targeting of Mutated EGFR(T790M) with
Chlorofluoroacetamide-Pyrimidines.ACS
Med Chem Lett. [Epub ahead of print], 2020 Jun 11
Kusunose N, Tsuruta A, Kengo Hamamura, Tsurudome Y, Yoshida Y, Akamine
T, Matsunaga N, Koyanagi S, Ohdo S.
Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular
clock in mouse Peyer's patches.
Genes Cells. [Epub ahead of print], 2020 Feb 12
Uchinomiya S, Matsunaga N, Kamoda K, Kawagoe R, Tsuruta A, Ohdo S, Ojida
A.
Fluorescence detection of metabolic activity of the fatty acid beta oxidation
pathway in living cells.
Chem Commun (Camb). [Epub ahead of print], 2020 Feb 5
2019年
Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor
Erastin in Human Breast Cancer Xenograft Mice.
Biol Pharm Bull. [Epub ahead of print], 2019 Nov 1
Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga
N, Koyanagi S, Ohdo S.
Estradiol regulation of P-glycoprotein expression in mouse kidney and human
tubular epithelial cells, implication for renal clearance of drugs.
Biochem Biophys Res Commun. [Epub ahead of print], 2019 Sep 17
Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura
A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo
S, Nishida M.
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation
of TRPC3-Nox2 protein complex.
Br J Pharmacol. [Epub ahead of print], 2019 Jun 26
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacological strategies focused on chrono-drug discovery.
Pharmacol Ther. [Epub ahead of print], 2019 Jun 4
Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S,
Ohdo S.
Microcurrent stimulation activates the circadian machinery in mice.
Biochem Biophys Res Commun. [Epub ahead of print], 2019 Feb 26
Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto
K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M,
Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo
S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Nat Chem Biol. [Epub ahead of print], 2019 Jan 14
2018年
Katamune C, Koyanagi S, Hashikawa K, Kusunose N, Akamine T, Matsunaga N,
Ohdo S.
Mutation of the gene encoding the circadian clock component PERIOD2 in
oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
J Biol Chem. [Epub ahead of print], 2018 Nov 14
Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga
N, Koyanagi S, Ohdo S, Kubota T.
Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation
of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal
glial (Müller) cells.
Jpn J Ophthalmol. [Epub ahead of print], 2018 Sep 24
Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu
S, Koyanagi S, Ohdo S.
Epithelial cell adhesion molecule expression in hepatic stem/progenitor
cells is controlled by the molecular clock system.
Biochem Biophys Res Commun. [Epub ahead of print], 2018 Jun 30
Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato
M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+
exchanger regulatory factor-1 and its scaffolding function.
Sci Rep. [Epub ahead of print], 2018 Jun 13
Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Accumulation of sorbitol in the sciatic nerve modulates circadian properties
of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse
model.
Biochem Biophys Res Commun. [Epub ahead of print], 2018 May 9
Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.
Optimized dosing schedule based on circadian dynamics of mouse breast cancer
stem cells improves the anti-tumor effects of aldehyde dehydrogenase.
Cancer Res. [Epub ahead of print], 2018
Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor
activity in breast tumor-bearing mice.
J Pharmacol Sci. 2018 Mar12
Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura
K, Koyanagi S, Ohdo S.
Angiotensin-II regulates dosing time-dependent intratumoral accumulation
of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing
mice.
Biochem Biophys Res Commun. 2018 Feb 19
2017年
Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo
S.
Periodic variation in bile acids controls circadian changes in uric acid
via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.
J Biol Chem. [Epub ahead of print], 2017
Okazaki F, Matunaga N, Hamamura K, Suzuki K, Nakao T, Okazaki H, Kutsukake
M, Fukumori S, Tsuji Y, To H.
Administering xCT inhibitors based on circadian clock improves antitumor
effects.
Cancer Res. [Epub ahead of print], 2017
Hashikawa K, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Dysfunction of the circadian transcriptional factor CLOCK in mice resists
chemical carcinogen-induced tumorigenesis.
Sci Rep. 7(1):9995, 2017
Dilixiati A, Koyanagi S, Kusunose N, Matunaga N, Ohdo S.
Dietary supplementation with essence of chicken enhances daily oscillations
in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted
environmental light-dark cycle in mice.
J Pharmacol Sci. 134(4):211-217, 2017
Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Matsunaga N, Koyanagi
S, Ohdo S.
Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial
cardiolipin peroxidation in renal tubular epithelial cells.
Eur J Pharmacol. 800:48-56, 2017
2016年
Tomohiro Shibata, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Satoshi
Hattori, Chihiro Fukumitsu, Yuichi Murakami, Ryuji Takahashi, Uhi Toh,
Ken-ichi Ito, Shigehiro Ohdo, Maki Tanaka, Masayoshi Kage, Michihiko Kuwano
and Mayumi Ono
Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation
and ERBB2 Expression
Cancer Res. 77(2):545-556, 2016.
Mahitab Elsayed, Daisuke Kobayashi, Toshio Kubota, Naoya Matsunaga, Ryusei
Murata, Yuko Yoshizawa, Natsuki Watanabe, Tohru Matsuura, Yuya Tsurudome,
Takashi Ogino, Shigehiro Ohdo, Takao Shimazoe
Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin
on Human Pancreatic Cancer Cell Lines: An in Vitro Study
Biol Pharm Bull. 39(8):1238-46, 2016.
Yuki Nakamura, Nobuhiro Nakano, Kayoko Ishimaru, Noriko Ando, Ryohei Katoh,
Katsue Suzuki-Inoue, Satoru Koyanagki, Hideoki Ogawa, Ko Okumura, Shigenobu
Shibata, Atsuhito Nakao
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting
the circadian clock
J Allergy Clin Immunol. 137(4):1226-1235, 2016.
Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda
T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, ohdo S.
Glucocorticoid regulation of ATP release from spinal astrocytes underlies
diurnal exacerbation of neuropathic mechanical allodynia.
Nat Commun. 7:13102, 2016.
Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama
H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino
T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto
T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S.
Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic
Kidney Disease.
EBioMedicine. pii: S2352-3964(16)30463-7, 2016. [Epub ahead of print]
Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S,
Ohdo S.
Different roles of negative and positive components of the circadian clock
in oncogene-induced neoplastic transformation.
J Biol Chem. 291:10541-10550, 2016.
Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Hara Y, Tsuruta
A, Tsurudome Y, Ogino T, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H,
Aramaki H, Koyanagi S, Ohdo S.
Circadian clock in a mouse colon tumor regulates intracellular iron levels
to promote tumor progression.
J Biol Chem. 291:7017-7028, 2016.
Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho
K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto
T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
Alterations of hepatic metabolism in chronic kidney disease via D-box binding
protein aggravate the renal dysfunction.
J Biol Chem. 291:4913-4927, 2016.
2015年
Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo
S, Kubota T.
Mitomycin C modulates the circadian oscillation of clock gene Period 2
expression through attenuating the glucocorticoid signaling in mouse fibroblasts.
Biochem Biophys Res Commun. S0006-291: 30603-3, 2015.
Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguchi M, Matsunaga
N, Ohdo S.
Dosing time-dependent changes in the analgesic effect of pregabalin on
diabetic neuropathy in mice.
J Pharmacol Exp Ther. 354: 65-72, 2015.
Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi
M, Izumi T, Ohdo S.
Circadian modulation in the intestinal absorption of P-glycoprotein substrates
in monkeys.
Mol Pharmacol. 87: 314-322, 2015.
Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga
N, Ohdo S.
Modulation of peroxisome proliferator-activated receptor-α activity by
bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4
in mice.
Mol Pharmacol. 88: 29-37, 2015.
2014年
Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata
S, Ohdo S.
Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα)
activity underlies circadian expression of intestinal peptide absorption
transporter PepT1/Slc15a1.
J Biol Chem. 289: 25296-25305, 2014.
Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.
Renal circadian clock regulates the dosing-time dependency of Cisplatin-induced
nephrotoxicity in mice.
Mol Pharmacol. 85: 715-722, 2014.
Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe
M, Koyanagi S, Ohdo S.
24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by
Molecular Clocks.
J Invest Dermatol. [Epub ahead of print], 2014.
Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono
M, Kuwano M, Koyanagi S, Ohdo S.
Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.
Cancer Res. 74: 543-551, 2014.
2013年
Matsunaga N, Okazaki F, Koyanagi S, Ohdo S.
Chrono-drug delivery system based on the circadian rhythm of transferrin
receptor.
Nihon Rinsho. 71: 2200-2205, 2013.
Tomishima Y, Ishitsuka Y, Matsunaga N, Nagatome M, Furusho H, Irikura M,
Ohdo S, Irie T.
Ozagrel hydrochloride, a selective thromboxane A?Esynthase inhibitor, alleviates
liver injury induced by acetaminophen overdose in mice.
BMC Gastroenterol. 13: 21-30, 2013.
Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita
C, Ohdo S.
Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation
of p53 in Malignant Cells.
Cancer Res. 73: 2639-2649, 2013.
Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo
S.
Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression
in Mouse Ventral Striatum.
Mol Pharmacol. 83: 959-967, 2013
Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda
E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of
Parkinson's Disease.
Neuromolecular Med. 15: 238-251, 2013
2012年
Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto N,
Teramoto N, Fujita K, Ohdo S, Iguchi H.
IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung
Tumor Cells in the Brain.
Int J Mol Sci. 14: 515-526, 2012.
Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo
S.
Role of activating transcription factor-4 in 24-hour rhythm of serotonin
transporter expression in the mouse midbrain.
Mol Pharmacol. 82: 264-270, 2012.
Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo
S.
Intestinal expression of mouse Abcg2/Bcrp gene is under the control of
circadian clock-activating transcription factor-4 pathway.
J Biol Chem. 287: 17224-17231, 2012.
Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi
A, Yoshimura Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S.
Time-dependent Interaction Between DEC2 and C/EBPα Underlies the Circadian
Expression of CYP2D6 in Serum-shocked HepG2 Cells.
Mol Pharmacol. 81: 739-747, 2012.
Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.
Stress-regulated transcription factor ATF4 promotes neoplastic transformation
by suppressing expression of the INK4a/ARF cell senescence factors.
Cancer Res. 72: 395-401, 2012.
2011年
Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a
CLOCK-dependent circadian manner.
Toxicology.204-8, 2011.
Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N,
OhdoS.
cAMP-response Element (CRE)-mediated Transcription by Activating Transcription
Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene.
J Biol Chem.286: 32416-23, 2011.
Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.
Molecular basis of chronopharmaceutics.
J Pharm Sci.100: 3560-76, 2011.
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacology.
Nihon Yakurigaku Zasshi.137: 115-9, 2011. Review.
Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.
Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse
primary hepatocytes.
Toxicology.280: 144-51, 2011.
2010年
Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda
M, Inoue K, Ohdo S.
Molecular basis for the dosing time-dependency of anti-allodynic effects
of gabapentin in a mouse model of neuropathic pain.
Mol. Pain. 6: 83, 2010.
Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda
E, Ohdo S, Shimeno H, Soeda S.
Proxisome proliferator-activated receptor-alpha mediates high-fat, diet-enhanced
daily oscillation of plasminogen activator inhibitor-1 activity in mice.
Chronobiol. Int. 27: 1735-1753, 2010.
Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S.
Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell
death of mouse rectum carcinoma.
J. Pharmacol. Sci. 113: 353-361, 2010.
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacological strategies: Intra- and inter-individual variability of
molecular clock.
Adv. Drug Deliv. Rev. 62: 885-897, 2010.
Okazaki F, Matsunaga, N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi
S, Ohdo, S.
Circadian rhythm of transferrin receptor 1 gene expression controlled by
c-Myc in colon cancer-bearing mice.
Cancer Res. 70: 6238-6246, 2010.
Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto
Y, Shimeno H, Soeda S, Ohdo S.
Bezafibrate induces plasminogen activator inhibitor-1 gene expression in
a CLOCK-dependent circadian manner.
Mol. Pharmacol. 78: 135-141, 2010.
Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K,Koyanagi S,
Ohdo, S.
Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase
gene modulates dacarbazine-induced hepatotoxicity in mice.
J. Pharmacol. Exp. Ther. 333: 782-787, 2010.
2009年
Kim J, Matsunaga N, Koyanagi S, Ohdo S.
Clock gene mutation modulates the cellular sensitivity to genotoxic stress
through altering the expression of N-methylpurine DNA glycosylase gene.
Biochem Pharmacol.78(8),1075-1082,2009.
2008年
Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S.
Circadian clock-controlled intestinal expression of the multidrug-resistance
gene mdr1a in mice.
Gastroenterology 135: 1636-1644, 2008.
Matsunaga N, Ikeda M, Takiguchi T, Koyanagi S, and Ohdo S.
The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in
the mouse liver.
Hepatology 48: 240-251, 2008.
Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S.
Dosing schedule-dependent change in the disruptive effects of interferon-alpha
on the circadian clock function.
Life Sci. 83: 574-580, 2008.
Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H,
Soeda S, Ohdo S.
Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting
platelet-derived growth factor signaling.
J. Pharmacol. Sci. 107: 401-407, 2008.
Terazono H, Hamdan A, Matsunaga N, Hayasaka N, Kaji H, Egawa T, Makino
K, Shigeyoshi Y, Koyanagi S, Ohdo S.
Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian
clock genes: A possible mechanism of chemotherapy-induced circadian rhythm
disturbances.
Biochem. Pharmacol. 75: 1616-1622, 2008.
2007年
Takiguchi T, Tomita M, Matsunaga N, Nakagawa H, Koyanagi S, Ohdo S.
Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2
cells.
Pharmacogenet. Genomics 17:1047-1056, 2007.
2006年
Koyanagi S, Suyama H, Kuramoto Y, Matsunaga N, Takane H, Soeda S, Shimeno
H, Higuchi S, Ohdo S.
Glucocorticoid regulation of 24-hour oscillation in interferon receptor
gene expression in mouse liver.
Endocrinology 147: 5037-5040, 2006.
Yamauchi A, Ichimiya T, Inoue K, Taguchi Y, Matsunaga N, Koyanagi S, Fukagawa
T, Aramaki H, Higuchi S, Ohdo S.
Cell cycle dependent pharmacology of methotrexate in HL-60
J. Pharmacol. Sci. 99: 335-341, 2006.
-2005年
Yamauchi A, Ichimiya T, Inoue K, Taguchi Y, Matsunaga N, Koyanagi S, Fukagawa
T, Aramaki H, Higuchi S, Ohdo S.
Cell cycle dependent pharmacology of methotrexate in HL-60.
J. Pharmacol. Sci. 99, 335-341, 2005.
Viyoch J, Matsunaga N, Yoshida M, To H, Higuchi S, Ohdo S.
Effect of haloperidol on mPer1 gene expression in mouse SCN.
J. Biol. Chem. 280 (8) 6309-6315, 2005.
Matsunaga N, Nakamura N, Yoneda N, Qin T, Terazono H, To H, Higuchi S, Ohdo S. Influence of feeding schedule on 24-h rhythm of hepatotoxicity induced by acetaminophen in mice. J. Pharmacol. Exp. Ther. 311(2)594-600,2004.
To H, Shin M, Tabuchi M, Sakaguchi H, Takeuchi A, Matsunaga N, Higuchi
S, Ohdo S. Influence of dosing schedule on toxicity and antitumor effects
of a combination of adriamycin and docetaxel in mice. Clin.Cancer. Res.10(2):762-9,
2004.